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Unveiling Pathways: Inspiring Insights from Prof. Jing Wang’s Voyage in Biomedical Engineering

Allow me to introduce Professor Jing Wang, an accomplished figure in the field of biomedical engineering, whose journey traverses continents and academic milestones. Having completed her Ph.D. outside the US, she embarked on a trajectory that led her to prestigious postdoctoral roles at Duke University and the University of Michigan before assuming the mantle of Assistant Professor at Iowa State University in 2022. With a background rooted in medical engineering and a passion for cancer studies, Professor Wang’s desire to create solutions with translational value propelled her to the forefront of her field.

Her trajectory highlights her tenacity in pursuing knowledge across borders and contributing to the realm of biomedical engineering. Her affinity for biology and her dedication to practical applications echo her commitment to making a tangible difference in the world. Speaking on the challenges encountered by Asian women faculty members in STEM, she aptly noted, “For female scientists, there are always a lot of family responsibilities… women have to take more responsibility or more job to take care of the family, the kids, and then the parents.” This candid insight underscores the delicate balance between professional aspirations and familial duties that many women navigate. She, however, remains hopeful, acknowledging the availability of policies and benefits that support these talented individuals in managing these demands.

Addressing collaboration dynamics, Professor Wang observed, “Especially when you start collaboration, you will find it’s still like a lot of male scientists in this field.” While gender disparities persist, she highlighted the proactive role played by organizations like NIH and NSF in fostering collaborations that embrace diversity. She finds inspiration in the numerous successful female faculty members in the field of biomedical engineering, regarding them as role models who have navigated similar challenges and emerged triumphant.

In the realm of biomedical innovation, Professor Jing Wang’s journey stands as a testament to dedication and groundbreaking research. Her efforts are poised to inspire students and researchers to bridge critical gaps in medicine and the biomedical field. Among her notable accomplishments, Professor Wang’s research took an intriguing turn, focusing on immunoregulation and cancer metastasis. Over the course of four years at the University of Michigan, her dedication to understanding immunotherapy’s nuances crystallized. Notably, her recent publication in Nature Communications marked a significant milestone.

In her words,

“Our study uncovered the intricate interplay of immune cells in breast cancer hosts, shedding light on why some patients experience lung metastasis while others achieve long-term survival.”

Professor Wang

Navigating the intricate landscape of scientific discovery, Professor Jing Wang’s journey has been enriched by the guidance of remarkable mentors. As she elaborates, “I am very lucky. I always encounter very good mentors. A good mentor should give you scientific suggestions about your project because they know more than you.” For Professor Wang, mentorship has been a dual path of guidance and empowerment. The pivotal role of mentors in fostering independence is evident, as she highlights, “During this training, probably the postdoc already have a lot of ideas about how to design a project, how to bring up different hypotheses. So, a good mentor should always encourage the postdoc to try their new ideas rather than telling them step by step what they want you to do.” This approach has been pivotal in cultivating her independent researcher capabilities and fostering a collaborative yet explorative spirit.

In a world of scientific pursuit, Professor Jing Wang’s advice shines as a beacon of encouragement for young Asian women entering STEM fields, particularly in biomedical engineering. “I believe people who choose this field are really interested in it, and I can see a lot of opportunities in academia and in industry,” she emphasizes. Undoubtedly, the presence of successful women in the field signifies the potential for future achievements. Addressing concerns of discrimination or challenges, she assures aspiring scientists to confidently embrace the field and its boundless possibilities. Professor Wang’s insights resonate with the inspiring narrative of determined women who continue to thrive and make their mark in the realm of STEM.

Professor Jing Wang’s journey through biomedical engineering is a testament to determination and innovation. Her dedication to addressing challenges and making a tangible impact is inspiring. Aspiring Asian women in STEM can find encouragement in her story. For more insights, watch the interview, where she shares her experiences and wisdom.

Faculty Profiles

Professor Jing Wang

Meet Dr. Jing Wang, an accomplished Assistant Professor at Iowa State University. With a Ph.D. in Biomedical Engineering from the Chinese Academy of Sciences and a B.S. in Biology and Biotechnology from Peking University, Dr. Wang’s academic journey is marked by excellence. Drawing from her postdoctoral experiences at Duke University and the University of Michigan, she specializes in nanotechnology-driven drug delivery, protein engineering, immunotherapy, and pioneering research on cancer metastasis and lung diseases. Her work, based at the Biorenewables Research Laboratory, exemplifies her dedication to advancing biomedical science and contributing to transformative breakthroughs.

Education

Ph.D. Biomedical Engineering, Chinese Academy of Sciences

B.S.   Biology and Biotechnology, Peking University

Email: jwang1@iastate.edu

Welcome to Jing’s Lab

Publications

Wang J, Hall M, Bushnell, G, Orbach S, Decker J, Raghani R, Zhang Y, Morris A, Jeruss J*, Shea L*. A lung-mimicking synthetic metastatic niche reveals N1 neutrophils drive breast cancer metastatic dormancy in the lungs. 2021. (Under Review)

Wang J, Youngblood R, Cassinotti L, Skoumal M, Corfas G*, Shea L*. An injectable PEG hydrogel controlling neurotrophin-3 release by affinity peptides. Journal of Controlled Release, 2021, 330, 575-586.

Wang J, Min J, Ali Eghtesadi S, Kane R, Chilkoti A*. Quantitative study of the interaction of multivalent ligand-modified nanoparticles with breast cancer cells with tunable receptor density. ACS Nano, 2020, 14, 372-383.

Wang J, Saha S, Schaal JL, Yousefpour P, Li X, Chilkoti A*. Heuristics for the optimal presentation of bioactive peptides on polypeptide micelles. Nano Letters, 2020, 19, 7911-7987.

 Wang J, Dzuricky M, Chilkoti A*. The weak link: optimization of ligand-nanoparticle interface to enhance cancer cell targeting by hydrophobic peptide-decorated polymer micelles. Nano Letters, 2017, 17, 5995-6005.

 Wang J, Bhattacharyya J, Mastria E, Chilkoti A*. A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles. Journal of Controlled Release, 2017, 260, 100-110. Wang J, MacEwan SR, Chilkoti A*. Quantitative mapping of the spatial distribution of nanoparticles in endo-lysosomes by local pH. Nano Letters, 2016, 17, 1226-1232.

Liu J, Liu W, Weitzhandler I, Bhattacharyya J, Li X, Wang J, Qi Y, Bhattacharjee S, Chilkoti A*. Ring-opening polymerization of prodrugs: a versatile approach to prepare well-defined drug-loaded nanoparticles. Angewandte Chemie International Edition, 2015, 54, 1002-1006.

Qin L, Zhang F, Lu X, Wei X, Wang J, Fang C, Si D, Wang Y, Zhang C, Yang R, Liu C, Liang W*. Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors. Journal of Controlled Release, 2013, 171, 133-142.

 Wang J, Xing X, Fang X, Zhou C, Huang F, Lou J*, Liang W*. Cationic amphiphilic drugs self-assemble to the core-shell interface of PEGylated phospholipid micelles and stabilized micellar structure. Philosophical Transactions of the Royal Society A. Mathematical, Physical and Engineering Sciences, 2013, 371, 20120309.

Wang J, Fang X, Liang W*. Pegylated phospholipid micelles induce endoplasmic reticulum-dependent apoptosis of cancer cells but not normal cells. ACS Nano, 2012, 6, 5018-5030.

Wang J, Wang Y, Liang W*. Delivery of drugs to cell membranes by encapsulation in PEG-PE micelles. Journal of Controlled Release, 2012, 160, 637-651.

Wang J, Qu H, Jin L, Zeng W, Qin L, Zhang F, Wei X, Lu W, Zhang C*, Liang W*. Pegylated phosphotidylethanolamine inhibiting P-glycoprotein expression and enhancing retention of doxorubicin in MCF7/ADR cells. Journal of Pharmaceutical Sciences, 2011, 100, 2267-2777.

Wang J, Liang W*. Effects of nanomaterials on cellular structure and function. Acta Biophysica Sinica, 2010, 26, 613-622.

Liang W*, Wang J, Wang Y. Advances in the structure and function of nanometer assemblies. Acta Biophysica Sinica. 2009, S1, 64-65.

Diversity and Determination: Professor Li’s Impact in STEM

Welcome to our interview with Professor Li, an accomplished academic in the field of electrical engineering and industrial engineering. Professor Li’s journey in STEM began in China, where she pursued her undergraduate studies in electrical engineering. Seeking further opportunities, she moved to the United States and earned her master’s degree in electrical engineering from the University of Rochester. However, her passion for statistics led her to switch her focus to a PhD in statistics at Virginia Tech.

After completing her doctorate, Professor Li worked as a visiting assistant professor at the University of Wisconsin-Madison’s Department of Statistics before finally joining Iowa State University’s Industrial Engineering Department in 2018. Join us as we explore her inspiring journey in academia and her valuable contributions to the field of engineering.

In my conversation with Professor Li shared the challenges she faced as a female student in a male-dominated field during her undergraduate years. Being the only female student in her cohort at the beginning, she felt isolated and struggled with some hands-on experiments. However, she resiliently overcame these obstacles by changing cohorts, finding support among other female students, and forming study groups to enhance her learning experience. Professor Li’s journey exemplifies the importance of seeking camaraderie and support in overcoming challenges and succeeding in academia.

Dr. Li touched upon the representation of women in the field of engineering, especially in higher education and professional careers. While the undergraduate ratio of female students appears relatively higher, the numbers gradually decrease as one progresses to graduate studies and faculty positions. Professor Li emphasizes that gender differences in interests and family responsibilities contribute to this trend, with many women facing challenges while balancing career aspirations and family obligations. As she candidly shares her personal experience of recovery after childbirth, Professor Li sheds light on the realities that impact the representation of women in STEM fields.

“For undergraduate students, maybe in general, there are 30% of female students. And then as you move higher in education, the ratio is decreasing.”

Professor Li

The disparity in gender representation becomes evident as women advance in their academic and professional journeys, with a noticeable decline in the number of female students pursuing higher education and tenure-track faculty positions. This observation highlights the need for continued efforts to promote gender diversity and inclusivity in engineering and STEM fields, ensuring that more women are encouraged to pursue careers and excel in these domains.

“The biggest challenge for females is especially when they go to their career, they’re at the age of having children, taking care of their family, etc. I think that’s very challenging for most females.”

Professor Li

Professor Li sheds light on her current research endeavors in the field of industrial engineering, focusing on quality-related studies in advanced manufacturing, particularly in areas like 3D printing. Her work also extends to healthcare data analytics, utilizing the vast amount of data collected in hospitals to aid healthcare practitioners in decision-making and resource allocation. Through her research, Professor Li strives to enhance manufacturing processes, product quality, and healthcare outcomes.

Professor Li, she shares valuable advice for aspiring Asian women entering the STEM field: “Do not give up.” Drawing from her own experiences, she emphasizes the importance of perseverance, even during challenging times. Despite facing doubts and difficulties along her academic journey, the encouragement from friends, family, and mentors kept her going. Professor Li’s story serves as a powerful reminder of the transformative impact of determination and resilience in achieving one’s goals, making her an inspiring role model for aspiring women in STEM.

In conclusion, Professor Nancy Li’s journey in STEM is a testament to the power of determination and the importance of mentorship in overcoming challenges. As a female academic in traditionally male-dominated fields, she has faced isolation and gender differences, but her unwavering perseverance and support from mentors have propelled her forward. For a more comprehensive insight into Professor Li’s inspiring journey, we invite you to watch the full interview provided above.

Seizing Opportunities: Dr. Lu Liu’s Inspiring Journey in STEM

Welcome to our interview with Dr. Lu Liu, an accomplished researcher in the field of civil engineering and environmental science. Originally from China, Lu’s journey in STEM began at the University of Oklahoma, where she earned her bachelor’s and master’s degrees in environmental science. Driven by a passion for sustainable engineering, she pursued a Ph.D. in civil engineering, culminating in her graduation in 2017. Following her academic pursuits, Lu’s expertise led her to work as a postdoctoral researcher at Rice University before embarking on her current role as a faculty member at Iowa State University since the fall of 2021. Join us as we delve into her inspiring journey and the impact of her work in the realm of STEM.

In our insightful interview with Dr. Lu Liu, a passionate researcher in civil engineering and environmental science, she shared the motivation behind her chosen field, driven by a deep concern for environmental issues prevalent in her home country, China. Her interest in water resources and water scarcity issues fueled her academic pursuits, leading her to earn her bachelor’s and master’s degrees in environmental science with a focus on water resources. As she embarked on her journey as a young Asian female faculty member, Lu encountered challenges in student perceptions, noting the influence of her identity on their reactions. Despite these obstacles, she remains hopeful that time will help bridge the gap and foster a more inclusive learning environment.

“It started from my home country, the environmental issues there bothered me, and I wanted to do something about it while in school.” Dr. Lu Liu

In her journey through civil engineering and environmental science, Dr. Lu Liu exemplifies the transformative power of pursuing one’s passion. With a strong desire to address environmental problems, particularly water-related issues in her home country, she delved into the field of environmental science and civil engineering. As a young Asian female faculty member, she acknowledges the unique challenges that come with her identity in a traditionally conservative field. Her experiences serve as a reminder of the importance of promoting diversity and inclusion in STEM, creating spaces where all individuals can thrive and contribute their unique perspectives.

“Engineering, especially civil engineering, is a very traditional type of study. They haven’t seen many faces like this, so they’re kind of skeptical.”

Dr. Lu Liu

In our enlightening conversation with Dr. Lu Liu, a dedicated researcher in civil engineering and environmental science, she shared her diverse professional journey, which includes brief stints in industry and valuable experiences in a nonprofit organization. While working in the traditional oil and gas industry didn’t align with her passion, her time in the nonprofit sector provided her with invaluable skills in grantsmanship and networking. Lu’s insight highlights the hidden potential and career growth opportunities that nonprofit organizations offer, urging students to consider them as valuable learning experiences.

Dr. Liu also shed light on the changes she observed in the STEM field for Asian women since joining Iowa State University. Although there has been some progress in increasing the number of female faculty, she noticed that the percentage of female students in the department has remained stagnant. In her pursuit of improving diversity and inclusion, Lu emphasizes the importance of increasing female faculty representation as it could positively influence female student recruitment. Moreover, she was surprised to discover that her department had its first female full professor only a few years ago, despite its 150-year history, exposing the need for further progress in gender equality in academia.

Dr. Lu Liu shared a recent memorable achievement in her research journey. Co-writing a news article about flooding in the U.S. with her male colleague, they published it on an online platform called The Conversation, dedicated to public education about STEM topics. Surprisingly, their article garnered widespread readership and caught the attention of organizers from the Indiana Water Summit. As a result, they were invited to speak at the prestigious water summit in August—an opportunity that came unexpectedly but highlighted the power of seizing chances and being courageous.

Lu’s experience offers valuable insights for junior faculty, especially Asian females, who may sometimes doubt their qualifications or hesitate to take up opportunities. Her male colleague’s encouragement served as a reminder that self-belief and confidence are crucial in navigating the academic landscape. Driven by a desire to challenge skepticism, Lu’s journey exemplifies the potential rewards of being open to new opportunities and showcasing expertise in the field of water resources.

“We wanna take the opportunities as much as we can, and also be courageous about it.”

Dr. Lu Liu

Dr. Lu Liu’s success story serves as an inspiration, encouraging individuals, especially women in academia, to embrace their expertise and contribute fearlessly to scientific discourse. By sharing her achievements and experiences, Lu empowers others to break free from self-doubt and seize the unexpected paths that can lead to transformative opportunities and recognition in their respective fields.

Gain a deeper understanding of Dr. Lu Liu’s remarkable journey in STEM by watching the full interview provided above. As an environmental scientist and civil engineer, she shares her motivations for addressing environmental problems, particularly water scarcity issues. Dr. Liu candidly discusses the challenges she faced as an Asian female faculty member in a traditional field like civil engineering, emphasizing the importance of diversity and inclusion in academia. 

Unwavering Perseverance: The Inspiring Journey of Professor Anwesha Sarkar in STEM

Welcome to our interview with Professor Anwesha Sarkar, an esteemed physicist whose journey in STEM was ignited by a powerful influence – her mother, a math teacher, and an inspiring figure who dedicated herself to helping struggling students. Growing up in India, Anwesha’s fascination with physics never waned, leading her to pursue a bachelor’s in Physics at St. Xavier’s College, Master’s in Physics at IIT Madras, M.Phil. in Physics at the Institute of Physics in India, and PhD in Physics at Wayne State University. With a passion for STEM and a deep love for physics, Anwesha’s journey exemplifies the power of dedication and the importance of strong female role models in the world of science. 

Throughout her academic journey, Anwesha remained steadfast in her pursuit of physics, thriving in institutions where the male-to-female student ratio was heavily skewed. Undeterred, she embraced the challenge and excelled in her studies, showcasing her natural aptitude for the subject. Her decision to focus on physics was further solidified as she ventured into bioengineering and biophysics collaborations, exploring exciting intersections between physics and biology.

Anwesha’s passion for physics extends beyond her research and academic achievements. As an enthusiastic mentor, she takes joy in nurturing young minds and fostering a love for science among her students. Her commitment to uplifting others echoes the impact her mother had on her own journey, emphasizing the profound influence that supportive and encouraging role models can have on aspiring scientists.

Professor Anwesha Sarkar’s journey in STEM has been both inspiring and challenging, navigating through different universities and fields from physics to bioengineering. As an Asian woman in a predominantly male-dominated field, she encountered various perceptions and biases. While she was fortunate to have supportive colleagues and friends, she also witnessed instances of gender-based discrimination and biased treatment. Throughout her experiences, Anwesha emphasizes the importance of surrounding oneself with people who uplift and value diversity, irrespective of gender or background.

In this enlightening interview, Professor Anwesha Sarkar shared her remarkable journey from being captivated by physics in India to becoming a distinguished researcher in the field of biophysics and bioengineering. Through her groundbreaking work using atomic force microscopy, she delves into live cell imaging and protein-protein interactions, paving the way for improved drug delivery carriers and novel therapeutic approaches in targeting diseases like cancer and fibrosis. Anwesha’s dedication and expertise have been recognized with prestigious grants and awards, including Exploratory Research grant (ERP) in 2020 and 2021, SVPP term faculty professional development grant in 2020 and 2021, Translational AI Center SEED grant 2023 and an NSF (CMMI) grant in 2022. Moreover, her commitment to mentoring underrepresented minority students in STEM, evident through her active involvement with WISE and INSPIRE, showcases her passion for fostering inclusive and diverse research environments.

“I actively mentor underrepresented minority undergrad students through WISE and INSPIRE. They are not just struggling with passing courses; they have a ton of problems going on in their life. So helping them in any way I can should be our motto.”

Professor Sarkar

In her inspiring advice to new Asian female students entering STEM, Professor Anwesha Sarkar emphasizes the power of perseverance and unique qualities that they possess. She encourages them to push through challenges, starting anew each day and utilizing their strengths to forge ahead. Recognizing the importance of happiness in one’s work, she highlights the significance of surrounding oneself with confident and supportive individuals, whether mentors, friends, or family. Anwesha’s message underscores the value of a strong support system that believes in one’s aspirations and fosters an environment of growth and empowerment.

As she describes in her own words, “As Asian women in STEM, you have already shown extreme perseverance. Keep building, build on those experiences, and push through. Start where you are and surround yourself with happy and confident people who will never drag you down but only add value to your life.”

Recognizing the significance of a strong support system, Anwesha highlights the role of mentors, friends, and family in providing encouragement and guidance. As an Asian woman in STEM herself, she emphasizes the need to be part of a community that understands the unique struggles and triumphs that come with the journey. Anwesha’s empowering message resonates with the idea that progress is not solely about gender but about fostering an environment of growth and empowerment for all aspiring women in STEM.

“Our support system chooses us. Make sure you have those kind of people, confident and happy in their own life. They will believe in you and what you want to do.”

Professor Sarkar

Professor Anwesha Sarkar’s remarkable journey serves as a beacon of inspiration for aspiring scientists, especially Asian women, in the world of STEM. Her unwavering dedication to physics and her passion for nurturing young minds showcase the transformative impact of supportive role models. Through her pioneering research, mentorship, and advocacy, Professor Sarkar’s impact on the academic community resonates far beyond her own accomplishments, inspiring a new era of aspiring researchers to embrace their passion and create positive change in the world of science.

For a more comprehensive insight into Professor Anwesha Sarkar’s inspiring journey in STEM, we invite you to watch the full interview in the video provided above. Through this interview, you will gain a deeper understanding of her experiences, challenges, and triumphs as she navigated through different fields and universities, from physics to bioengineering.

Faculty Profiles

Professor Anwesha Sarkar

Introducing Dr. Anwesha Sarkar, an accomplished Assistant Professor at Iowa State University. With a diverse academic background spanning multiple continents, her expertise lies in the fascinating realm of Single Molecule Biophysics, Atomic Force Microscopy, and Protein-protein interactions. As a vital contributor to the Nanovaccine Institute, Dr. Sarkar’s research delves into the cutting-edge world of biosensors and bioengineering, propelling advancements in the field of nanovaccines. Her journey is a testament to the power of interdisciplinary collaboration and the pursuit of scientific excellence.

Education 
  • Postdoctoral Research Associate, Iowa State University (2020) PhD
  • Physics, Wayne State University (2015) MPhil, Physics
  • Institute of Physics, India (2011) MSc,
  • Physics, IIT Madras, India (2010) BSc,
  • Physics, ST. Xavier’s College, Kolkata, India (2008)  

Email: anweshas@iastate.edu

BACM LAB – Research Laboratory of Professor Anwesha Sarkar

Publications
  • Waite, J., Tana, S., Saha, H., Sarkar, S., Sarkar, A. (2022). Few-shot Deep Learning for AFM Force Curve Characterization of Single Molecule Interactions. Accepted in Patterns
  • Rade, J., Zhang, J., Sarkar, S., Krishnamurthy, A., Ren, J., & Sarkar, A. (2022). Deep Learning for Live Cell Shape Detection and Automated AFM Navigation. Bioengineering, 9(10), 522.
  • Sarkar, A. (December 2021). Biosensing, characterization of biosensors, and improved drug delivery approaches using Atomic Force Microscopy: A review. Frontiers in Nanotechnology
  • Sarkar, A*., Mao, S.*, Wang, Y., Song, C., LeVine, D., Wang, X., and Que, L. (2021). Microfluidic chip grafted with integrin tension sensors for evaluating the effects of flowing shear force and ROCK inhibitor on platelets. Lab on a chip, (* made equal contribution and they share the first authorship)
  • Sarkar, A., LeVine, D. N., Kuzmina, N., Zhao, Y., & Wang, X. (2020). Cell migration driven by self-generated integrin ligand gradient on ligand-labile surfaces. Current Biology, 30(20), 4022-4032. doi: https://doi.org/10.1016/j.cub.2020.08.020
  • Sarkar, A., LeVine, D., Zhao, Y., Mollaeian, K., Ren, J., & Wang, X. (2020). Tandem tension sensor reveals substrate rigidity-dependence of integrin molecular tensions in live cells. bioRxiv. doi: https://doi.org/10.1101/2020.01.24.918946
  • Zhao, Y., Sarkar, A., & Wang, X. (2020). Peptide nucleic acid based tension sensor for cellular force imaging with strong DNase resistance. Biosensors and Bioelectronics, 150, 111959. doi: https://doi.org/10.1016/j.bios.2019.111959
  • Wang, Y., Zhao, Y., Sarkar, A., & Wang, X. (2019). Optical sensor revealed abnormal nuclease spatial activity on cancer cell membrane. Journal of biophotonics, 12(5), e201800351. DOI: 10.1002/jbio.201800351
  • Sarkar, A., Zhao, Y., Wang, Y., & Wang, X. (2018). Force-activatable coating enables high-resolution cellular force imaging directly on regular cell culture surfaces. Physical biology, 15(6), 065002. doi: 10.1088/1478-3975/aac69d
  • Wang, Y., LeVine, D. N., Gannon, M., Zhao, Y., Sarkar, A., Hoch, B., & Wang, X. (2018). Force-activatable biosensor enables single platelet force mapping directly by fluorescence imaging. Biosensors and Bioelectronics, 100, 192-200. DOI: 10.1016/j.bios.2017.09.007
  • Zhao, Y., Wang, Y., Sarkar, A., & Wang, X. (2018). Keratocytes generate high integrin tension at the trailing edge to mediate rear De-adhesion during rapid cell migration. Iscience, 9, 502-512. doi: https://doi.org/10.1016/j.isci.2018.11.016
  • Sarkar, A.#, Sohail, A., Dong, J., Prunotto, M., Shinki, K., Fridman, R., & Hoffmann, P. M. (2019). Live cell measurements of interaction forces and binding kinetics between Discoidin Domain Receptor 1 (DDR1) and collagen I with atomic force microscopy. Biochimica et Biophysica Acta (BBA)-General Subjects, 1863(11), 129402. DOI: 10.1016/j.bbagen.2019.07.011
  • Jones, S. K., Sarkar, A.#, Feldmann, D. P., Hoffmann, P., & Merkel, O. M. (2017). Revisiting the value of competition assays in folate receptor-mediated drug delivery. Biomaterials, 138, 35-45. doi: https://doi.org/10.1016/j.biomaterials.2017.05.034
  • J. Rade, S. Sarkar, A. Krishnamurthy, A. Sarkar, Virtual AFM: Generating Synthetic 2D Multi-view Images from 3D Protein Structure, Biomedical Engineering Society (BMES) Annual meeting, San Antonio, TX, 2022.
  • A. Koep, A. Sarkar, S. Alam, T. Prozorov, I. Schneider, Actuatable Hollow DNA Origami Drug Delivery Constructs, Biomedical Engineering Society (BMES) Annual meeting, San Antonio, TX, 2022.
  • J. Rade, S. Sarkar, A. Sarkar, A. Krishnamurthy, 3D Reconstruction of Protein Complex Structures Using Synthesized Multi-View AFM Images, Machine Learning in Structural Biology (MLSB) Workshop at the 36th Conference on Neural Information Processing Systems (NeurIPS), New Orleans, LA, 2022.
  • A. Sarkar, N. Hassan, R. Bardhan, Multimodal characterization of live cancer cells using Atomic Force Microscopy and Raman spectroscopy, presented as a poster, Biophysical Society 66th Annual Meeting, San Francisco, CA 2022.
  • A. Sarkar, S. Yang, B. Chen, High Resolution Single Molecule Imaging of WRC-Rac1 Protein Complex with Atomic Force Microscopy, Biomedical Engineering Society (BMES) Annual meeting, Orlando, Fl 2021.
  • J. Rade, S. Sarkar, A. Krishnamurthy, J. Ren, A. Sarkar, AI Guided Measurement of Live Cells Using AFM, Modelling, Estimation and Control Conference (MECC), Austin, TX 2021.
  • A. Sarkar, J. Waite, S. Sarkar, Deep learning for fast Atomic Force Microscopy data analytics, selected for platform presentation and presented as a talk, Biophysical Society 65th Annual Meeting (virtual) 2021.
  • S. Mao~ , A. Sarkar ~, D. LeVine, X. Wang, L. Que, Studies of the drug treatment effects on platelets using integrative tension sensors embedded in a microfuidic chip, Microfluidics for Hematology, presented as talk, Chicago, IL 2020 (~ made equal contribution and share the first authorship)
  • A. Sarkar, Y. Wang, X. Wang, Determining Integrin Molecular Tension for the Recruitment and the activation of Focal Adhesion Kinase, Biophysical Society (BPS), 63rd Annual meeting, presented as poster, Baltimore, MD 2019.
  • A. Sarkar, X. Wang, Integrin molecular tensions in live cells are altered by substrate rigidity, Biophysical Society (BPS), 62nd Annual meeting, presented as a talk and poster, San Francisco, CA 2018 [the work was also presented as a talk and poster in the ISU Research Day, Iowa State University, 2018]
  • A. Sarkar, R. Fridman, A. Sohail and P. M. Hoffmann, Measurement of DDR-Collagen interaction Forces with Atomic force Microscopy, American Physical Society (APS) March Meeting, San Antonio, TX 2015
  • A. Sarkar, E. Mayyas and P. M. Hofmann, Effect of Surface Density of Active sites on Rupture Force Distributions of Single Molecule Interactions, Biophysical Society (BPS), 59th Annual Meeting, Baltimore, MD 2015
  • A. Sarkar and P. M. Hoffmann, Effect of active site density on rupture force distributions in ligand-protein force measurements, American Physical Society (APS) Ohio-Region Section Meeting, April 2014, Youngstown, OH (presented as poster) [the work was also presented during the Physics Graduate Research Day, Wayne State University, April 2014]
  • A. Sarkar, E. Kramkowski, E. Mayyas and P. M. Hoffmann, Multiple attachments, heterogeneous binding and the high force tail in protein-protein binding force histograms, American Physical Society (APS) March Meeting, March 2013, Baltimore, MD (presented as poster) [the work was also presented during the Physics Graduate Research Day, Wayne State University, April 2013]
  • A. Sarkar, E. Kramkowski and P. M. Hoffmann, Live cell imaging and determination of protein-protein rupture force with AFM, American Physical Society (APS) Ohio-Region Section Meeting, October 2012, Detroit, MI (presented as poster) [the work was also presented in Michigan Microscopy and Microanalysis Society Fall 2012 Meeting]

From Microbiology to Environmental Engineering: Dr. Kaoru Ikuma’s Journey in Academia and Advocacy for Diversity of Thoughts

Dr. Kaoru Ikuma’s journey in academia is a testament to her unwavering determination and love for learning. Born in Japan, she spent a significant part of her childhood in the United States, igniting an early fascination with the diverse world around her. Pursuing her passion for biology and biochemistry, she obtained her undergraduate degrees before making a bold switch to environmental engineering, a field where she could merge her interests seamlessly.

Her thirst for knowledge led her to a profound love for research during her master’s degree, propelling her to pursue a Ph.D. from a different institution. As a dedicated researcher, she thrived in discovering new insights and delving into intricate details. Surpassing her passion for research, Dr. Ikuma discovered her profound joy in mentoring, nurturing meaningful connections with her students and peers. Embarking on postdoctoral positions to expand her expertise and research horizons, she eventually found her way to Iowa State University in 2015. In 2022, she achieved tenure, marking a pivotal milestone in her distinguished career.

A single class ignited her passion for the deep mysteries of environmental microbiology, a discipline with boundless potential and endless discoveries. As she ventured deeper into the realm of environmental engineering, Dr. Ikuma came to realize the profound impact this field has on everyday life, supporting wellbeing, health, and even survival. From a love for microbiology to the pursuit of environmental engineering, Dr. Ikuma found herself drawn to a vocation where her efforts would go beyond the limelight, serving as a silent guardian for society. The enchantment of environmental engineering lies in its ability to create seamless experiences in our lives, allowing us to open a tap and receive clean, safe water without a second thought.

“I wanted to be one of the people who are in the behind-the-scenes supporting society.”

dR. iKUMA

This sense of purpose became all too real for Dr. Ikuma when she experienced the devastation of a powerful earthquake in Japan. The loss of running water for two months left an indelible mark, highlighting the immense importance of clean water in our daily lives. This experience resonated deeply as she began her journey in environmental engineering, reinforcing her commitment to being part of the force that safeguards society from such hardships.

In the words of Dr. Kaoru Ikuma, “Not having water and how very difficult it is to get clean water was something that always stuck with me and then kind of came back full circle when I started learning about environmental engineering. I realized that I wanted to be one of the people who are in the, the behind the scenes supporting society.”

Dr. Kaoru Ikuma brings a unique perspective to her field as an Asian woman in STEM field. She believes that the diversity of thought is a powerful asset, and her experiences have shown her that she thinks differently from many of her colleagues. In her view, this diversity of perspective is vital, especially in a field like environmental engineering, where the connections to society and human health are profound. Dr. Ikuma emphasizes the importance of women’s voices being heard and their perspectives considered in STEM fields, making her an inspiring advocate for diversity and inclusion.

In her own word’s Dr. Ikuma share, “”That diversity of thought is a good thing. And I think it’s important across STEM fields. But I really feel it in environmental engineering because we’re so tied into society and tied into human health and wellbeing that our perspective as women and women of color, women who see the world a little bit differently, is important to consider and important to be heard.”

Dr. Ikuma highlights an important point of creating an inclusive environment. It is vital, ensuring that diverse perspectives are valued and heard, without trying to homogenize individuals who may look different but think the same. To achieve this, a concerted effort is needed from all stakeholders, including students, faculty, staff, parents, and industry partners, to emphasize the significance of diversity, equity, and inclusion. Dr. Ikuma emphasizes that this conscious effort must be clearly articulated and upheld at all levels of education and professional settings.

“We’re that is entirely missing the point. I don’t, I think it’s okay for people to look the same, but have different opinions, that’s actually even more important or, you know, will help a lot.”

Dr. ikuma

From microbiology to environmental engineering, Dr. Ikuma’s unwavering passion for learning and discovery has led her to advocate for inclusive environments and diversity of thought. As an Asian woman in STEM, her inspiring story highlights the importance of fostering progress and innovation through embracing diversity in academia.

Experience the full conversation with Professor Kaoru Ikuma in the interview video! This written blog offers just a glimpse of our insightful discussion, where she shares her journey, motivations, and perspectives as a woman of color in the STEM field. Don’t miss the opportunity to hear directly from her about the importance of diversity of thought and creating an inclusive environment in academia and beyond. Click above to watch the full interview and gain deeper insights into Professor Ikuma’s remarkable work and experiences.

Faculty Profiles

Professor Qing Li

Meet Qing Li, an Assistant Professor at Iowa State University’s Department of Industrial and Manufacturing Systems Engineering and Center of Nondestructive Evaluation. With a diverse academic background in Statistics, Electrical Engineering, and Information and Electronics Engineering, Dr. Li brings a wealth of knowledge and expertise to her role. Her research interests encompass a wide range of areas, including quality assurance, data analytics in advanced manufacturing, Bayesian analysis, and statistical machine learning, making her a valuable asset to the field of engineering and natural science applications of statistics and machine learning.

Education                                                                                   
  • PhD, Statistics, Virginia Tech, 2015
  • MS, Electrical Engineering, University of Rochester, 2010
  • BE, Information and Electronics Engineering, Tsinghua University, 2008

Learn more about Professor Qing Li’s work

Publications

Fringe projection profilometry by conducting deep learning from its digital twinY Zheng, S Wang, Q Li, B LiOptics Express 28 (24), 36568-36583622020
Multistate travel time reliability models with skewed component distributionsF Guo, Q Li, H RakhaTransportation Research Record 2315 (1), 47-53552012
Monitoring the Long-Distance Transport of Fusarium graminearum from Field-Scale Sources of InoculumAJ Prussin, Q Li, R Malla, SD Ross, DG Schmale IIIPlant Disease 98 (4), 504-511512014
Correlation approach for quality assurance of additive manufactured parts based on optical metrologyX Zhang, Y Zheng, V Suresh, S Wang, Q Li, B Li, H QinJournal of Manufacturing Processes 53, 310-317312020
Similarity evaluation of topography measurement results by different optical metrology technologies for additive manufactured partsY Zheng, X Zhang, S Wang, Q Li, H Qin, B LiOptics and Lasers in Engineering 126, 105920262020
Design criteria for adaptive roadway lightingRB Gibbons, F Guo, A Medina, TN Terry, J Du, PJ Lutkevich, Q LiUnited States. Federal Highway Administration252014
Evaluation of risk change-point for novice teenage driversQ Li, F Guo, SG Klauer, BG Simons-MortonAccident Analysis & Prevention 108, 139-146232017
Counting cats for conservation: seasonal estimates of leopard density and drivers of distribution in the SerengetiML Allen, S Wang, LO Olson, Q Li, M KrofelBiodiversity and Conservation 29, 3591-3608212020
A Bayesian state-space model using age-at-harvest data for estimating the population of black bears (Ursus americanus) in WisconsinML Allen, AS Norton, G Stauffer, NM Roberts, Y Luo, Q Li, D MacFarland, …Scientific Reports 8 (1), 12440212018
A Bayesian finite mixture change-point model for assessing the risk of novice teenage driversQ Li, F Guo, I Kim, SG Klauer, BG Simons-MortonJournal of Applied Statistics 45 (4), 604-625202017
In situ monitoring of direct energy deposition via structured light system and its application in remanufacturing industryX Zhang, W Shen, V Suresh, J Hamilton, LH Yeh, X Jiang, Z Zhang, Q Li, …The International Journal of Advanced Manufacturing Technology 116 (3-4 …132021
E-CatBoost: An efficient machine learning framework for predicting ICU mortality using the eICU Collaborative Research DatabaseN Safaei, B Safaei, S Seyedekrami, M Talafidaryani, A Masoud, S Wang, …Plos one 17 (5), e026289572022
Similarity quantification of 3D surface topography measurementsY Jiang, S Wang, H Qin, B Li, Q LiMeasurement 186, 11020772021
A non-parametric Bayesian change-point method for recurrent eventsQ Li, F Guo, I KimJournal of Statistical Computation and Simulation 90 (16), 2929-294872020
A change-point detection and clustering method in the recurrent-event contextQ Li, K Yao, X ZhangJournal of Statistical Computation and Simulation 90 (6), 1131-114962020
Similarity evaluation of 3D surface topography measurementsS Wang, X Zhang, Y Zheng, B Li, H Qin, Q LiMeasurement Science and Technology 32 (12), 12500352021
Linking Roadway Lighting and Crash SafetyR Gibbons, F Guo, J Du, A Medina, P Lutkevich, T Terry, Q LiTransportation Research Board 94th Annual MeetingTransportation Research Board52015
In-depth evaluation of APACHE scoring system using eICU databaseA Rajabalizadeh, S Wang, M Javadi, N Safaei, M Talafidaryani, Q Li, …32020
Surface roughness measurement of additive manufactured parts using focus variation microscopy and structured light systemX Zhang, V Suresh, Y Zheng, S Wang, Q Li, H Lyu, B Li, H QinInternational Manufacturing Science and Engineering Conference 58745 …32019
Recurrent-event models for change-points detectionQ LiVirginia Tech
Approaches to adaptive lighting on roadwaysRB Gibbons, F Guo, A Medina, J Du, T Terry, P Lutkevich, Q LiTransportation Research Record 2485 (1), 26-3232015
Similarity evaluation of 3D topological measurement results using statistical methods (Rising Researcher)V Suresh, Y Zheng, X Zhang, S Wang, H Qin, Q Li, B LiDimensional Optical Metrology and Inspection for Practical Applications IX …22020
Bayesian change-points detection assuming a power law process in the recurrent-event contextQ Li, L Liu, T Li, K YaoCommunications in Statistics-Simulation and Computation, 1-2312021
Investigating the relationship of porcine reproductive and respiratory syndrome virus RNA detection between adult/sow farm and wean-to-market age categoriesY Jiang, Q Li, G Trevisan, DCL Linhares, C MacKenziePlos one 16 (7), e025342912021
Multi-modal in-situ nondestructive testing of direct energy deposition and AI-enabled data fusion for quality assurance in remanufacturingW Shen, L Liu, X Jiang, Z Zhang, Q Li, H QinIIE Annual Conference. Proceedings, 1-62022
Assessing the First Year of GAPS (Graduates for Advancing Professional Skills) ProgramS Jiang, N Reuel, G Okudan-Kremer, Q Li, R Mort, D Chen2021
Assessing the First Year of GAPS (Graduates for Advancing Professional Skills) ProgramA Gansemer-Topf, S Jiang, N Reuel, G Okudan-Kremer, Q Li, R Mort, …2021 ASEE Midwest Section Conference2021
Similarity evaluation of topography measurement results by different optical metrology technologies for additive manufactured parts (vol 126, 105920, 2020)Y Zheng, X Zhang, S Wang, Q Li, H Qin, B LiOPTICS AND LASERS IN ENGINEERING 1392021
MD-Manifold: A Medical Distance Based Manifold Learning Approach for Heart Failure Readmission PredictionS Wang, Q Li, W Zhang2021
A Community of Practice Approach to Integrating Professional Skills Training with Graduate Thesis ResearchG Okudan Kremer, S Jiang, Q Li, A Gansemer-Topf, N Reuel, R Mort2020
A Community of Practice Approach to Integrating Professional Skills Training with Graduate Thesis ResearchS Jiang, AM Gansemer-Topf, NF Reuel, GE Okudan-Kremer, Q Li, R MortSouth Dakota State University2020
Implementing Professional Skills Training in STEM: A Review of the LiteratureAM Gansemer-Topf, Q Li, S Jiang, GE Okudan-Kremer, NF Reuel2020
ICU outcome prediction using real-time signals with wavelet-transform-based convolutional neural network

Faculty Profiles

Dr. Lu Liu

Introducing Dr. Lu Liu, an esteemed Assistant Professor in Civil, Construction, and Environmental Engineering at Iowa State University. With an impressive educational background, including a Ph.D. in Civil Engineering from the University of Maryland, Dr. Liu’s research interests center around the critical Water-Energy-Climate nexus, urban water sustainability, and climate change adaptations. Currently involved in several active projects, her work is dedicated to advancing environmental resilience and sustainability, making her a valuable asset to the academic community.

Education
  • Ph.D. Civil Engineering, University of Maryland, 2017
  • M.S. Environmental Science, University of Oklahoma, 2012
  • B.S. Environmental Science, University of Oklahoma, 2010

Email: luliu@iastate.edu

Publications

Water-energy-climate nexus

(1)      Zhang, X.; Li, H.-Y.; Leung, L. R.; Liu, L.; Hejazi, M. I.; Forman, B. A.; Yigzaw, W. River Regulation Alleviates the Impacts of Climate Change on U.S. Thermoelectricity Production. J. Geophys. Res. Atmos. 2020125 (4), e2019JD031618. https://doi.org/10.1029/2019JD031618.

(2)      Liu, L.; Hejazi, M.; Iyer, G.; Forman, B. A. Implications of Water Constraints on Electricity Capacity Expansion in the United States. Nat. Sustain. 20192 (3), 206–213. https://doi.org/10.1038/s41893-019-0235-0.

(3)      Liu, L.; Parkinson, S.; Gidden, M.; Byers, E.; Satoh, Y.; Riahi, K. Quantifying the Potential for Reservoirs to Secure Future Surface Water Yields in the World ’ s Largest River Basins OPEN ACCESS Quantifying the Potential for Reservoirs to Secure Future Surface Water Yields in the World ’ s Largest River Basins. Environ. Res. Lett. 201813https://doi.org/10.1088/1748-9326/aab2b5.

(4)      Li, X.; Vernon, C. R.; Hejazi, M. I.; Link, R. P.; Huang, Z.; Liu, L.; Feng, L. Tethys – A Python Package for Spatial and Temporal Downscaling of Global Water Withdrawals. J. Open Res. Softw. 20186 (1). https://doi.org/10.5334/jors.197.

(5)      Voisin, N.; Hejazi, M. I.; Leung, L. R.; Liu, L.; Huang, M.; Li, H.-Y.; Tesfa, T. Effects of Spatially Distributed Sectoral Water Management on the Redistribution of Water Resources in an Integrated Water Model. Water Resour. Res. 201753 (5), 4253–4270. https://doi.org/https://doi.org/10.1002/2016WR019767.

(6)      Liu, L.; Hejazi, M.; Li, H.; Forman, B.; Zhang, X. Vulnerability of US Thermoelectric Power Generation to Climate Change When Incorporating State-Level Environmental Regulations. Nat. Energy 20172, 17109. https://doi.org/10.1038/nenergy.2017.109.

(7)      Talati, S.; Zhai, H.; Kyle, G. P.; Morgan, M. G.; Patel, P.; Liu, L. Consumptive Water Use from Electricity Generation in the Southwest under Alternative Climate, Technology, and Policy Futures. Environ. Sci. Technol. 201650 (22), 12095–12104. https://doi.org/10.1021/acs.est.6b01389.

(8)      Scott, M. J.; Daly, D. S.; Hejazi, M. I.; Kyle, G. P.; Liu, L.; McJeon, H. C.; Mundra, A.; Patel, P. L.; Rice, J. S.; Voisin, N. Sensitivity of Future U.S. Water Shortages to Socioeconomic and Climate Drivers: A Case Study in Georgia Using an Integrated Human-Earth System Modeling Framework. Clim. Change 2016136 (2), 233–246. https://doi.org/10.1007/s10584-016-1602-8.

(9)      Kim, S. H.; Hejazi, M.; Liu, L.; Calvin, K.; Clarke, L.; Edmonds, J.; Kyle, P.; Patel, P.; Wise, M.; Davies, E. Balancing Global Water Availability and Use at Basin Scale in an Integrated Assessment Model. Clim. Change 2016136 (2), 217–231. https://doi.org/10.1007/s10584-016-1604-6.

(10)      Li, H.-Y.; Ruby Leung, L.; Tesfa, T.; Voisin, N.; Hejazi, M.; Liu, L.; Liu, Y.; Rice, J.; Wu, H.; Yang, X. Modeling Stream Temperature in the Anthropocene: An Earth System Modeling Approach. J. Adv. Model. Earth Syst. 20157 (4), 1661–1679. https://doi.org/10.1002/2015MS000471.

  • (11)      Liu, L.; Hejazi, M.; Patel, P.; Kyle, P.; Davies, E.; Zhou, Y.; Clarke, L.; Edmonds, J. Water Demands for Electricity Generation in the U.S.: Modeling Different Scenarios for the Water-Energy Nexus. Technol. Forecast. Soc. Change201594, 318–334. https://doi.org/10.1016/j.techfore.2014.11.004.
  • (12)      Hejazi, M. I.; Voisin, N.; Liu, L.; Bramer, L. M.; Fortin, D. C.; Hathaway, J. E.; Huang, M.; Kyle, P.; Leung, L. R.; Li, H.-Y.; Liu, Y.; Patel, P. L.; Pulsipher, T. C.; Rice, J. S.; Tesfa, T. K.; Vernon, C. R.; Zhou, Y. 21st Century United States Emissions Mitigation Could Increase Water Stress More than the Climate Change It Is Mitigating. Proc. Natl. Acad. Sci. 2015112 (34), 10635–10640. https://doi.org/10.1073/pnas.1421675112.
  • (13)      Voisin, N.; Liu, L.; Hejazi, M.; Tesfa, T.; Li, H.; Huang, M.; Liu, Y.; Leung, L. R. One-Way Coupling of an Integrated Assessment Model and a Water Resources Model: Evaluation and Implications of Future Changes over the US Midwest. Hydrol. Earth Syst. Sci.201317 (11), 4555–4575. https://doi.org/10.5194/hess-17-4555-2013.
  • Urban water sustainability
  • (14)      Liu, L.; Lopez, E.; Dueñas-Osorio, L.; Stadler, L.; Xie, Y.; Alvarez, P. J. J.; Li, Q. The Importance of System Configuration for Distributed Direct Potable Water Reuse. Nat. Sustain.2020https://doi.org/10.1038/s41893-020-0518-5.
  • (15)      Zhou, X.; Dueñas-Osorio, L.; Doss-Gollin, J.; Liu, L.;  Stadler, L.; Li, Q. Mesoscale Modeling of Distributed Water Systems Enables Policy Search. Water Resources Research.2023https://doi.org/10.1029/2022WR033758.
  • Climate change impact on water resources
  • (16)      Hong, Y.; Liu, L.; Qiao, L.; Adhikari, P. Climate Change and Hydrological Hazards. In Handbook of Engineering Hydrology; Eslamian, S., Ed.; Taylor & Francis Group, 2014; pp 53–70. https://doi.org/https://doi.org/10.1201/b16683.
  • (17)      Zhang, N.; Hong, Y.; Qin, Q.; Liu, L. VSDI: A Visible and Shortwave Infrared Drought Index for Monitoring Soil and Vegetation Moisture Based on Optical Remote Sensing. Int. J. Remote Sens.201334 (13), 4585–4609. https://doi.org/10.1080/01431161.2013.779046.
  • (18)      Lu, L.; Yang, H.; Jonathan, L.; Rachel, R.; Bin, Y.; Zengxin, Z.; James, H.; Mark, S. Climatological Drought Analyses and Projection Using SPI and PDSI: Case Study of the Arkansas Red River Basin. J. Hydrol. Eng.201318 (7), 809–816. https://doi.org/10.1061/(ASCE)HE.1943-5584.0000619.
  • (19)      Liu, L.; Hong, Y.; Bednarczyk, C. N.; Yong, B.; Shafer, M. A.; Riley, R.; Hocker, J. E. Hydro-Climatological Drought Analyses and Projections Using Meteorological and Hydrological Drought Indices: A Case Study in Blue River Basin, Oklahoma. Water Resour. Manag.201226 (10), 2761–2779. https://doi.org/10.1007/s11269-012-0044-y.
  • (20)      Liu, L.; Hong, Y.; Hocker, J. E.; Shafer, M. A.; Carter, L. M.; Gourley, J. J.; Bednarczyk, C. N.; Yong, B.; Adhikari, P. Analyzing Projected Changes and Trends of Temperature and Precipitation in the Southern USA from 16 Downscaled Global Climate Models. Theor. Appl. Climatol.2012109 (3), 345–360. https://doi.org/10.1007/s00704-011-0567-9.

Faculty Profiles

Dr. Kaoru Ikuma

Meet Dr. Kaoru Ikuma, an accomplished Associate Professor and Cerwick Faculty Fellow at Iowa State University. Her research endeavors center around environmental microbiology and biotechnology, with a particular focus on biodegradation of hazardous contaminants and sustainable water and wastewater treatment. Beyond her scientific pursuits, Kaoru is a strong advocate for water security and environmental justice, seeking to make a positive impact in the realm of environmental biofilm microbiology. 

Education

  • Ph.D. Civil and Environmental Engineering, Duke University, 2011 
  • M.S. Environmental Sciences and Engineering, Virginia Polytechnic Institute and State University, 2007 
  • B.S. Biochemistry, Virginia Polytechnic Institute and State University, 2005 
  • B.S. Biology, Virginia Polytechnic Institute and State University, 2005

Email: kikuma@iastate.edu

Publication

  • Exploring Water Justice, Equity, and Security: Current Federally-Funded Projects
  • Croll H.C.*, Ikuma K., Ong S.K., Sarkar S. Systematic performance evaluation of reinforcement learning algorithms applied to wastewater treatment control optimization. Environmental Science & Technology 2023, in press. 
  • Croll H.*, Ikuma K., Sarkar S., Ong S.K. Reinforcement learning applied to wastewater treatment process control optimization: Approaches, challenges, and path forward. Critical Reviews in Environmental Science and Technology 2023. [doi.org/10.1080/10643389.2023.2183699]  
  • Brown P.*, Ikuma K., Ong S. K. Biological phosphorus removal and its microbial community in a modified full-scale activated sludge system under dry and wet weather dynamics. Water Research 2022, 216: 118338. [doi.org/10.1016/j.watres.2022.118338]
  • Spellman C. D., Daer S.*, Ikuma K., Silverman I., Goodwill J. E. Sulfite-activated ferrate for water reuse applications. Water Research 2022, 216: 118317. [doi:10.1016/j.waterres.2022.118317]
  • Daer S.*, Rehmann E., Rehmann J., Ikuma K. Development of resistance in Escherichia coli against repeated disinfection: Implications for water reuse. Frontiers in Environmental Science 2022, 14 March 2022. [doi:10.3389/fenvs.2022.855224]
  • Pinto-Vilar R.*, Ikuma K. Effects of soil surface chemistry in adsorption and activity of urease in a crude protein extract and its implications to biocementation applications. Catalysts 2022, 12(2): 230. [doi:10.3390/catal12020230]
  • Pinto-Vilar R.*, Ikuma K. Adsorption of urease as part of a complex protein mixture onto soil and its implications to enzymatic activity. Biochemical Engineering Journal 2021, 171: 108026. [10.1016/j.bej.2021.108026]
  • Daer S.*, Goodwill J. E., Ikuma K. Effect of ferrate and hypochlorite disinfection on the physiological and transcriptomic response of Escherichia coliWater Research 2021, 189: 116580. [doi:10.1016/j.waterres.2020.116580]
  • Kralles Z. T., Ikuma K., Dai N. Assessing disinfection byproduct risks for algal impacted surface waters and the effects of peracetic acid pre-oxidation. Environmental Science: Water Research & Technology 2020, 6: 2365. [doi:10.1039/d0ew00237b]
  • Lee J., Choi J., Fatka M., Swanner E., Ikuma K., Liang X.*, Leung T., Howe A. Improved detection of mcyA genes and their phylogenetic origins in harmful algal blooms. Water Research 2020, 176: 115730. [doi:10.1016/j.waterres.2020.115730]
  • Tan Y., Park J., Ikuma K., Evans E. A., Flamming J. J., Ellis T. G. Feasibility test of autotrophic denitrification of industrial wastewater in sequencing batch and static granular bed reactors. Water Environment Research 2020, 92: 749-758. [doi:10.1002/wer.1271] (accepted in 2019)
  • Ikuma K. and Rehmann C.R. Importance of extracellular DNA in the fate and transport of antibiotic resistance genes downstream of a wastewater treatment plant. Environmental Engineering Science 2020, 37 (2): 164-168. [doi:10.1089/ees.2019.0319] (accepted in 2019)
  • Hoang T., Alleman J., Cetin B., Ikuma K., Choi S. G. Sand and silty-sand soil stabilization using bacterial enzyme induced calcite precipitation (BEICP). Canadian Geotechnical Journal 2019, 56 (6): 808-822. [doi:10.1139/cgj-2018-0191]
  • Pruden A., Alcalde R. E., Alvarez P. J., Ashbolt N. J., Biscel H., Capiro N. L., Crossette E., Frigon D., Grimes K., Haas C. N., Ikuma K., Kappell A., LaPara T., Lee K., Li M., Li X., McNamara P., Seo Y., Sobsey M., Sozzi E., Navab-Daneshmand T., Nguyen T. H., Raskin L., Prieto Riquelme M. V., Vikesland P., Wigginton K., Zhou Z. Towards an environmental science and engineering framework for monitoring and mitigating antimicrobial resistance. Environmental Engineering Science 201835 (10):1005-1011. [doi:10.1089/ees.2017.0520]
  • Sturgeon S. R., Pilsner R., Arcaro K. F., Ikuma K., Wu H., Kim S. M., Chopra-Tandon N., Karpf A., Ziegler R. G., Schairer C., Balasubramanian R., Reckhow D. A. White blood cell DNA methylation and risk of breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO). Breast Cancer Research 201719: 94. [doi:10.1186/s13058-017-0886-6]
  • Schwartz G. E., Redfern L. K., Ikuma K., Gunsch C. K., Ruhl L. S., Vengosh A., Hsu-Kim H. Impacts of coal ash on microbial methyl mercury production and the methylating microbial community in anaerobic sediment slurries. Environmental Science: Processes & Impacts 201618: 1427-1439. [doi:10.1039/c6em00458j]
  • Ikuma K., Shi Z., Walker A. V., Lau B. L. T. Effects of protein species and surface physicochemical features on the deposition of nanoparticles onto protein-coated planar surfaces. RSC Advances 20166: 75491-75498. [doi:10.1039/C6RA13508K]
  • Muller J. F., Ghosh, S., Ikuma K., Stevens A. M., Love, N. G. Chlorinated phenol-induced physiological antibiotic resistance in Pseudomonas aeruginosaFEMS Microbiology Letters 2015362 (21): fnv172. [doi:10.1093/femsle/fnv172]
  • Ikuma K., Decho A. W., Lau B. L. T. When nanoparticles meet biofilms: Interactions guiding the environmental fate and accumulation of nanoparticles. Frontiers in Microbiology, 16 June 2015 [doi:10.3389/fmicb.2015.00591]
  • Chae S.-R., Hunt D. E., Ikuma K., Yang S., Cho J., Gunsch C. K., Liu J., Wiesner M. R. Aging of fullerene C60 nanoparticle suspensions in the presence of microbes. Water Research 201465: 282-289. [doi:10.1016/j.watres.2014.07.038]
  • Huang R., Carney R. P., Ikuma K., Stellacci F., Lau B. L. T. Effects of surface compositional and structural heterogeneity on nanoparticle-protein interactions: Different protein configurations. ACS Nano 20148 (6): 5402-5412. [doi:10.1021/nn501203k]
  • Ikuma K., Madden A. S., Decho A. W., Lau B. L. T. Deposition of nanoparticles onto polysaccharide-coated surfaces: Implications for nanoparticle-biofilm interactions. Environmental Science: Nano 20141 (2): 117-122. [doi:10.1039/C3EN00075C]
  • Lau B. L. T., Hockaday W. C., Ikuma K., Furman O., Decho A. W. A preliminary assessment of the interactions between capping agents of silver nanoparticles and environmental organics. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2013435: 22-27. [doi:10.1016/j.colsurfa.2012.11.065]
  • Ikuma K., Decho A. W., Lau B. L. T. The extracellular bastions of bacteria – A biofilm way of life. Nature Education Knowledge 20134 (2): 2. [http://www.nature.com/scitable/knowledge/ library/the-extracellular-bastions-of-bacteria-nbsp-a-100450088]
  • Ikuma K. and Gunsch C. K. Successful genetic bioaugmentation with Pseudomonas putida for toluene degradation in soil columns. Environmental Chemistry Letters 201311: 365-370. [doi:10.1007/s10311-013-0416-4]
  • Ikuma K. and Gunsch C. K. Functionality of the TOL plasmid under varying environmental conditions following conjugal transfer. Applied Microbiology and Biotechnology 201397 (1): 395-408. [doi:10.1007/s00253-012-3949-8]
  • Ikuma K., Holzem R. M., Gunsch C. K. Impacts of organic carbon availability and recipient bacteria characteristics on the potential for TOL plasmid genetic bioaugmentation in soil slurries. Chemosphere 201289 (2): 158-163. [doi:10.1016/j.chemosphere.2012.05.086]
  • Ikuma K. and Gunsch C. K. Genetic bioaugmentation as an effective method for in situ bioremediation: Functionality of catabolic plasmids following conjugal transfers. Bioengineered 20123 (4): 234-239 (invited addendum to Ikuma and Gunsch (2013) Applied Microbiology and Biotechnology article). [doi:10.4161/bbug.20551]
  • Ikuma K. and Gunsch C. K. Effect of carbon source addition on toluene biodegradation by an Escherichia coli DH5a transconjugant harboring the TOL plasmid. Biotechnology and Bioengineering 2010107 (2): 269-277. [doi:10.1002/bit.22808]